Week 13 Year 2
Wednesday, April 29th, 2009Journal
This week on placement I helped perform a skeletal survey on a patient with a condition called Monoclonal Gammopathy of unknown significance, often referred to as (MGUS). This condition is also sometimes referred to as paraproteinaemia. MGUS is often discovered by accident from a routine blood test. This is a condition which adversely affects the body’s white blood cells (plasma cells).
Although the immune system is composed of several types of cells working together, the main cell type of the immune system are lymphocytes: T cells and B cells. B cells respond to infection, they mature and change into plasma cells, which make the antibodies and help the body attack and kill germs.
Normal plasma cells are found in the bone marrow, they are an important part of the body’s immune system, and they produce proteins for the body, known as antibodies or immunoglobulins. Antibodies circulate in the blood attacking viruses and bacteria that may be present in the body.
When plasma cells become abnormal they can, in some cases, start producing abnormal antibodies. These antibodies will not fight infection as they are created by copies of the same plasma cell and are therefore just replications of themselves.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. If these abnormal plasma cells do not produce an actual tumour or mass and do not cause any other problems then it is known as
monoclonal gammopathy of undetermined significance (MGUS).
Although MGUS suffers have high level of antibodies, the levels are not as high as with patients who have other forms of cancers, e.g. lymphoma or myeloma. Patients with MGUS don’t need treatment; however they are monitored closely due
to having an increased chance of developing a disease that does need to be treated (like multiple myeloma). This condition affects both men and women and has no known cause.
Our patient had been diagnosed with the condition many years previously and was suffering with increased breathing problems and pain. The skeletal survey was performed due to her having MGUS. Nether I or the radiographer had no knowledge or understanding of this condition at all and our patient was extremely distressed and unwell with multiple problems. I decided then to research this condition and follow up the report.